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Moreover the expression of wild-type DLK in keratinocytes stimulated transglutaminase activity and the consequent formation of the cornified cell envelope, while a kinase-inactive variant of DLK did not. This Article First Published on January 28, doi: In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum. Articles by Germain, L. To whom correspondence may be addressed:

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In addition, cultured keratinocytes infected with a recombinant adenovirus expressing DLK exhibited morphological and biochemical changes, including a suprabasal localization, altered cell shape, compacted cytoplasm, DNA fragmentation, and the up-regulation of filaggrin, that are reminiscent of a terminally differentiated phenotype.

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This Article First Published on January 28, doi: Classifications Mechanisms of Signal Transduction. View this article with LENS. Although it is expected that the last phases of this process must be tightly regulated since it results in cell death, the signaling pathways involved in this induction remain ill defined.

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Responses Submit a Letter to the Editor. In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum. We now report that a single kinase, the mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase DLKacts in 0800 epidermis to promote the terminal differentiation of human keratinocytes.

Google Scholar Articles by Robitaille, H. Articles by Germain, L.

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Prev Next Table of Contents. Search for related content. To whom dkl may be addressed: Moreover the expression of wild-type DLK in keratinocytes stimulated transglutaminase activity and the consequent formation of the cornified cell envelope, while a kinase-inactive variant of DLK did not.

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Journal of Lipid Research. Submit your work to JBC.

Together these results identify DLK as a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification. In support of this notion, we showed that DLK expression was restricted to the granular layer in situ. Related Content Load related web page information.

You’ll be in good company. Abstract In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum.

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